Abstract: Since the unification of the two German states in 1990, antisemitic attitudes have been repeatedly polled in cross-sectional or longitudinal national surveys (e.g., the long-term GFE surveys). So far, comparative studies analyzing the development of antisemitism in East and West Germany over a longer time period are scarce. The study covers a time span of 30 years to investigate two forms of antisemitism (classical and secondary), especially with respect to inner-German differences. Applying model-based age-period-cohort analyses (APC) with a total of 19 available representative surveys (maximal period: 1991–2021), theory-driven hypotheses are tested. The statistical approach and respective findings are discussed with emphasis on several challenges accompanying the utilized heterogenous data and different survey modes. Findings reveal that life-cycle effects play a decisive role in the attitudinal development and distribution of antisemitic attitudes. Moreover, approval of antisemitism is to some extent cohort related in both East and West Germany, while disentangling period effects empirically poses challenges due to data limitations. Furthermore, the observed APC structures differ for classical and secondary antisemitism. The chapter concludes with a critical discussion of the results, limitations, and some further thoughts on the open science philosophy in applied social science research.